TIF1 alpha (TRIM24) Rabbit Polyclonal Antibody

CAT#: AP20510PU-N

TIF1 alpha (TRIM24) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of TIF1alpha antibody (Cat.-No.: AP510PU-N) in extracts from COLO cells.

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  Immunohistochemistry (IHC) analyzes of TIF1alpha antibody (Cat.-No.: AP510PU-N) in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of TIF1alpha protein.
  (region surrounding Gln1034)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 117 kDa
• Gene Name: Homo sapiens tripartite motif containing 24 (TRIM24), transcript variant 1
• Database Link:
  Entrez Gene 21848 MouseEntrez Gene 8805 Human
  UniProt ID O15164
• Background: The protein mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc binding domains (a RING, a B box type 1 and a B box type 2) and a coiled coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Synonyms: TIF1 alpha, TIF1A, TIF1, RNF82, RING finger protein 82

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transcription Factors