FOXE3 Rabbit Polyclonal Antibody

CAT#: AP20439PU-N

FOXE3 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of FOXE3 in extracts from K562 cell using FOXE3 / FKHL12 antibody (Cat.-No. AP20439PU-N.)

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  Immunohistochemistry analyses of FOXE3 in human prostate carcinoma tissue (Formalin-fixed, Paraffin-embedded) using FOXE3 / FKHL12 antibody (Cat.-No. AP20439PU-N).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin sections: 1/50-1/200.
  Western Blot: 1/500-1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of FOXE3 protein.
  (region surrounding Arg97)
• Formulation: Phosphate buffered saline (PBS) with 0.05% Sodium azide, approx. pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
  
• Predicted Protein Size: ~ 33 kDa
• Gene Name: forkhead box E3
• Database Link:
  Entrez Gene 30923 MouseEntrez Gene 171302 RatEntrez Gene 2301 Human
  UniProt ID Q13461
• Background: The human forkhead-box (FOX) gene family consists of at least 43 members, including FOXE3, a 288-amino acid protein. FOXE3 is a winged-helix transcription factor that plays a crucial role during the initial stages of lens development and closure of the lens vesicle. FOXE3 may also act as a factor that promotes survival and proliferation while preventing differentiation in the lens epithelium. As the posterior cells of the lens fiber begin to differentiate, expression of FOXE3 is limited to the undifferentiated cells coating the anterior surface of the lens. Congenital primary aphakia (CPA) is a rare developmental disorder caused by a null mutation in the FOXE3 gene that is identified by the absence of a lens. The development of CPA is normally stimulated during the fourth or fifth week of human embryogenesis.
• Synonyms: Forkhead box protein E3, FREAC8