Fos B (FOSB) Rabbit Polyclonal Antibody

CAT#: AP20229PU-N

Fos B (FOSB) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analyzes of FosB antibody (AP20229PU-N) in extracts from COS7 cells.

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  Immunohistochemistry analyzes of FosB antibody (AP20229PU-N) in paraffin-embedded human prostate carcinoma tissue.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunoflourescence: 1/500-1/1000.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of FosB protein.
• Formulation: Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen; purity is > 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 35 kDa
• Gene Name: FosB proto-oncogene, AP-1 transcription factor subunit
• Database Link:
  Entrez Gene 14282 MouseEntrez Gene 2354 Human
  UniProt ID P53539
• Background: Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein II,a stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the ‘leucine-zipper’ motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.
• Synonyms: G0S3, GOS3, GOSB

Reference Data

• Protein Families: Druggable Genome, Transcription Factors