Cytochrome p450 2C19 (CYP2C19) Rabbit Polyclonal Antibody

SKU AP17267PU-N

Cytochrome p450 2C19 (CYP2C19) rabbit polyclonal antibody, Purified

Product Data

• Application: IHC, WB
• Recommended Dilution: Western blot: 1/1000.; ELISA: 1/1,000. ; Immunohistochemistry on Paraffin Sections: 1/10-1/50.
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 257-285 amino acids from the Central region of Human CYP2C19.
• Specificity: This antibody detects CYP2C19 at Center.
• Buffer: PBS with 0.09% (W/V) Sodium Azide; State: Purified; State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: cytochrome P450 family 2 subfamily C member 19
• Database Link:
  P33261
• Background: CYP2C19 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within its gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes.
• Synonyms: Cytochrome P450 2C19, CYPIIC17, CYPIIC19, Cytochrome P450-254C
• Note: Molecular weight: 55931 Da

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Arachidonic acid metabolism, Drug metabolism - cytochrome P450, Linoleic acid metabolism, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Retinol metabolism