Cathepsin F (CTSF) (Center) Rabbit Polyclonal Antibody

SKU AP17257PU-N

Cathepsin F (CTSF) (Center) rabbit polyclonal antibody

Product Data

• Application: WB
• Recommended Dilution: Western blot: 1:50 - 1:100.; ELISA: 1:1,000.
• Reactivity: Human
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the Center region of human CTSF
• Specificity: This antibody detects Cathepsin F at Center, D276.
• Buffer: PBS with 0.09% (W/V) sodium azide; State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
• Conjugation: Unconjugated
• Storage: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: cathepsin F
• Database Link:
  Q9UBX1
• Background: Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF is a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway.
• Synonyms: CATSF, CTSF
• Note: Molecular weight: 53366 Da

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Lysosome