Munc 13 4 (UNC13D) Goat Polyclonal Antibody

SKU AP16521PU-N

Munc 13 4 (UNC13D) goat polyclonal antibody, Aff - Purified

Product Data

• Application: IHC, WB
• Recommended Dilution: ELISA: 1/128000.; Western Blot: 1 - 3 µg/ml.; Immunohistochemistry on paraffin sections: 2.5 µg/ml.
• Reactivity: Canine, Human, Mouse, Rat
• Antibody Host: Goat
• Clonality: Polyclonal
• Immunogen: Peptide with sequence C-ETQKHKKDLHPLFD, from the internal region of the protein sequence
• Specificity: This antibody reacts to Munc13-4 / UNC13D.
• Buffer: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin; State: Aff - Purified; State: Liquid purified Ig
• Concentration: lot specific
• Purification: Affinity chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: unc-13 homolog D
• Database Link:
  Q70J99
• Background: Secretion of the contents of cytolytic granules at the immunologic synapse is a highly regulated process essential for lymphocyte cytotoxicity. This process requires the rapid transfer of perforin containing lytic granules to the target cell interface, followed by their docking and fusion with the plasma membrane. Munc 13-4 localises with cytotoxic granules at the immunologic synapse. Munc 13-4 is essential for the priming step of cytolytic granule secretion preceding vesicle membrane fusion. There are two named isoforms.
• Synonyms: Protein unc-13 homolog D, Munc13-4

Reference Data