Cbl c (CBLC) (N-term) Rabbit Polyclonal Antibody

SKU AP11261PU-N

Cbl c (CBLC) (N-term) rabbit polyclonal antibody, Purified

Product Data

• Application: IHC, WB
• Recommended Dilution: ELISA: 1/1,000.; Western blot: 1/100-1/500.; Immunohistochemistry: 1/50-1/100.
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human Cbl-c.
• Specificity: This antibody is specific to Cbl (N-term).
• Buffer: PBS containing 0.09% (W/V) Sodium Azide as preservative.; State: Purified; State: Liquid purified Ig fraction.
• Concentration: lot specific
• Purification: Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: Cbl proto-oncogene C
• Database Link:
  Q9ULV8
• Background: Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
• Synonyms: CBL3, CBL-C, CBL-3, RING finger protein 57
• Note: Predicted MW: 52456 Da

Reference Data