Xanthine Oxidase (XDH) Guinea Pig Polyclonal Antibody

SKU AP09533SU-N

Xanthine Oxidase (XDH) guinea pig polyclonal antibody, Serum

Product Data

• Application: IHC, WB
• Recommended Dilution: Western BLot: 1/2000 (ECL).; Immunohistochemistry on Frozen Sections: 1/100-1/200.; Immunohistochemistry on Paraffin Sections: 1/100-1/200 (Microwave treatment required).; Incubation Time: 1 h at RT for immunohistochemistry.
• Reactivity: Bovine, Human, Mouse, Rat
• Antibody Host: Guinea Pig
• Clonality: Polyclonal
• Immunogen: Xanthine Oxidase purified from Bovine Milk Fat Globule Membrane (MFGM).
• Specificity: The antiserum reacts specifically with Xanthine Oxidase, a 150 kD polypeptide present in lactating mammary gland epithelium and in MFGM. No cross-reaction with other MFGM proteins.
• Buffer: State: Serum; State: Liquid Serum with 0.5 % BSA ; Preservative: 0.09% Sodium Azide
• Conjugation: Unconjugated
• Storage: Store undiluted short term at 2-8°C. ; Long term storage in aliquots at -20°C. Avoid freeze/thaw cylces.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: xanthine dehydrogenase
• Database Link:
  P47989
• Background: In normal tissues this enzyme exists predominantly as Xanthine Dehydrogenase which converts hypoxanthine and xanthine to uric acid, a critical plasma antioxidant. During ischemia, Xanthine Dehydrogenase is reversibly converted to the oxygen radical-producing Xanthine Oxidase by oxidation of essential sulfhydryl groups, or irreversibly, through limited proteolytic cleavage of the amino-terminus. Aldehyde Oxidase has a higher affinity for aldehydes than purines, but produces O2- in a manner very similar to Xanthine Oxidase because both oxidases possess nearly identical internal electron transport systems. ; Xanthine oxidase 150 kD polypeptide is present in the apical membrane of lactating mammary epithelium and in MFGM.
• Synonyms: Xanthine dehydrogenase/oxidase

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Caffeine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism