SIRP alpha (SIRPA) (C-term) Rabbit Polyclonal Antibody

SKU AP07735PU-N

SIRP alpha (SIRPA) (C-term) rabbit polyclonal antibody, Purified

Product Data

• Application: IF, IHC, WB
• Recommended Dilution: Immunocytochemistry.; Immunohistochemistry on Paraffin Sections: 2.5 µg/ml.; Western Blot: 1/1000 - 1/2000.
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic Peptide - KLH conjugated corresponding to amino acids near the carboxy terminus of Human SIRPa.
• Specificity: Recognizes CD172a / SIRPA.
• Buffer: Phosphate Buffered Saline PBS containing 0.02% Sodium Azide as preservative.; State: Purified; State: Liquid purified IgG fraction.
• Concentration: lot specific
• Purification: DEAE-column Chromatography.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: signal regulatory protein alpha
• Database Link:
  P78324
• Background: Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPa, SHPS-1, MyD-1, BIT and p84. SIRPa is a new gene family containing at least fifteen members. SIRPa is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2. SIRPa has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes.
• Synonyms: SHP substrate 1, SHPS-1, Sirp-alpha-2, Sirp-alpha-3, MyD-1 antigen, p84, BIT, MFR, MYD1, PTPNS1, SHPS1

Reference Data