PARC (CUL9) Rabbit Polyclonal Antibody
| Product Data | |
| Application | ELISA, IHC, IP, WB |
|---|---|
| Recommended Dilution | ELISA: 1/2000 - 1/10000. Immunohistochemistry on Paraffin Sections: 1/500. Immunoprecipitation. Western Blot: 1/500 - 1/1000. |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to Amino Acids 2503-2517 of Human Cullin-9 (C-terminus) coupled to KLH. |
| Buffer | State: Sterile filtered antiserum Preservative: 0.01% sodium azide |
| Purification | Delipidation and defibrination. |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | cullin 9 |
| Database Link | |
| Background | Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. PARC is a cullin family member that functions as a cytoplasmic anchor protein in p53-associated protein complexes. PARC regulates the subcellular localization of p53 and subsequent function. PARC forms a complex with p53 in the cytoplasm of unstressed cells and interacts with UBCH7 and UBCH8. PARC shows a cytoplasmic localization and is ubiquitously expressed in all tissues with highest expression in testis brain and kidney. |
| Synonyms | CUL-9, H7AP1, KIAA0708, PARC |
| Reference Data | |
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