5 HT1A (HTR1A) Rabbit Polyclonal Antibody

SKU AP06769PU-N

5 HT1A (HTR1A) rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: IF, IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.; Immunohistochemistry on paraffin sections: 1/50 - 1/200.; Immunofluorescence: 1/50 - 1/200.
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 291-340 of Human SR-1A.
• Specificity: This antibody detects endogenous levels of SR-1A protein.; (region surrounding Phe321)
• Buffer: Phosphate buffered saline (PBS), pH 7.2; State: Aff - Purified; State: Liquid purified Ig fraction; Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (>95% pure (SDS-PAGE))
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Predicted Protein Size: ~ 46 kDa
• Gene Name: 5-hydroxytryptamine receptor 1A
• Database Link:
  P08908
• Background: The members of the G protein-coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. β-adrenergic bound to adrenaline activates adenylyl cyclase, while α2-adrenergic receptor bound to adrenaline inhibits adenylyl cyclase. Like the α2-adrenergic receptor, serotonin receptor functions are also mediated by G proteins that inhibit the activity of adenylyl cyclase. The serotonin receptors have been classified into several categories,designated SR-1–7 (5HT1–7). Subtypes within the SR-1 group include SR-1A,-1B, -1D, -1E and -1F.
• Synonyms: 5-hydroxytryptamine receptor 1A, ADRB2RL1, ADRBRL1, 5-HT1A, 5-HT-1A

Reference Data