FGFR1 Oncogene Partner (FGFR1OP) Rabbit Polyclonal Antibody

SKU AP06118PU-N

FGFR1 Oncogene Partner (FGFR1OP) rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: IF, IHC, WB
• Recommended Dilution:

  Western blot: 1/500-1/1000.; Immunohistochemistry on Paraffin sections: 1/50-1/200.; Immunofluorescence: 1/50-1/200.

• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 341-390 of Human FGFR1 OP.
• Specificity: This antibody detects endogenous levels of FGFR1OP protein (region surrounding Asn371).
• Buffer: Phosphate buffered saline (PBS), pH 7.2.; State: Aff - Purified; State: Liquid purified Ig fraction; Preservative: 15 mM sodium azide
• Concentration: <span>1.0 mg/ml</span>
• Purification: Affinity chromatography using epitope-specific immunogen (> 95% pure by SDS-PAGE).
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Predicted Protein Size: ~43, 92 kDa
• Gene Name: FGFR1 oncogene partner
• Database Link:
  O95684
• Background: Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. These include the Flg receptor or FGFR-1, the Bek receptor or FGFR-2, FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human Flg maps to chromosome 8p11 and is alternatively spliced to produce several isoforms. Mutations in Flg are associated with Pfeiffer syndrome, a skeletal disorder characterized by craniosynostosis with deviation and enlargement of the thumbs and great toes, brachymesophalangy, with phalangeal ankylosis and a varying degree of soft tissue syndactyly. The Flg gene is also involved in chromosomal translocations with ZNF198, CEP110 and FOP, which may lead to stem cell leukemia lymphoma (SCLL).
• Synonyms: FGFR1 oncogene partner, FOP

Reference Data