ROBO1 Rabbit Polyclonal Antibody
Rabbit Polyclonal Anti-ROBO1 Antibody, Purified
Product Datasheet for 'AP05287SU-N'
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|Immunogen||Synthetic peptide derived from human ROBO1 protein|
|Formulation||Phosphate buffered saline with 0.08% sodium azide|
|Purification||Liquid purified Ig fraction
|Predicted Protein Size||175.7KDa|
|Gene Name||roundabout guidance receptor 1|
|Background||Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development. Defects in ROBO1 may be a cause of breast and lung cancer. ROBO1 maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer cell lines (SCLC) and in a breast cancer cell line.|
|Protein Families||Druggable Genome|
|Protein Pathways||Axon guidance|