SPTLC1 Rabbit Polyclonal Antibody

SKU AP05280PU-N

SPTLC1 rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: IHC, WB
• Recommended Dilution: Western Blot: (1-5 µg/ml).; Immunohistochemistry: (5-10 µg/ml).
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide derived from the Human Sserine Palmitoyltransferase enzyme
• Specificity: This antibody detects Serine Palmitoyltransferase 1, ubiquitously expressed.
• Buffer: Phosphate buffered saline with 0.08% Sodium Azide as preservative; State: Aff - Purified; State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Antigen Immunoaffinity Chromatography
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Predicted Protein Size: 52.7 kDa
• Gene Name: serine palmitoyltransferase long chain base subunit 1
• Database Link:
  O15269
• Background: Sphingolipids play essential roles in various cellular events, including proliferation, differentiation, senescence, apoptosis, and inflammatory responses. Serine palmitoyltransferase (SPT) is the initial and rate-limiting enzyme in the de novo sphingolipid biosynthesis, and thus regulates the level of sphingolipids in cells. Immunohistochemical study revealed widespread distribution of the enzyme with most strong expression in brain and digestive tract. Two subunits, SPT1 and SPT2 at a stoichiometry of 1:1, are involved in the enzymatic activity of SPT.
• Synonyms: Serine palmitoyltransferase 1, SPT 1, SPT1, LCB 1, LCB1

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Metabolic pathways, Sphingolipid metabolism