AGPAT2 Rabbit Polyclonal Antibody

CAT#: AP05177PU-N

AGPAT2 rabbit polyclonal antibody, Purified

Product Images

Western blot analysis using LPAAT-beta antibody on Human brain lysate.

Specifications

Product Data

• Applications: ELISA, WB
• Recommended Dilution: Western Blot: 5-10 µg/ml.
  Enzyme Immunoassay.
  Positive Control: Human Brain Lysate.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide derived from the LPAAT-beta protein.
• Specificity: This antibody detects Lysophosphatidic Acid Acetyltransferase beta.
• Formulation: Phosphate buffered saline with 0.08% Sodium Azide as preservative.
  State: Purified
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Ship on dry ice. Store (in aliquots) at -20°C only.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: 1-acylglycerol-3-phosphate O-acyltransferase 2
• Database Link:
  Entrez Gene 10555 Human
  UniProt ID O15120
• Background: Lysophospholipid Acyltransferases (LPLATs) catalyse the addition of fatty acyl moieties to the glycerol backbone of lysophospholipids . In addition to playing a crutial role in the synthesis of structural membrane components the LPLATs are also implicated in cellular signalling responses for cytokines, growth factors and other agonists. Cellular signalling through the interleukin 1 receptor in human mesangial cells and EL-4 cells proceeds by the activation of lysophosphatidic acid acyltransferase (LPAAT). Activation of LPAAT by interleukin 1 results in the generation of unsaturated phosphatidic acid species, that are crucial to the generation of diacylglycerol and interleukin 1 signalling. LPLATs are also involved in signalling for increased interleukin 2 synthesis through the T cell antigen receptor. Activation of T-cells via anti-CD3 stimulation has been shown to increase incorporation of polyunsaturated fatty acids into phosphatidylcholine via lysophosphatidylcholine acyltransferase. Activation of this enzyme is essential for the sustained activation and translocation of protein kinase C.
• Synonyms: 1-AGP acyltransferase 2, LPAAT-beta