Phosphatidic acid phosphatase type 2B (PLPP3) Rabbit Polyclonal Antibody

SKU AP05176PU-N

Phosphatidic acid phosphatase type 2B (PLPP3) rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: ELISA, WB
• Recommended Dilution: Western Blot.; Enzyme Immunoassay.
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide derived from the phosphatidic acid phosphatase 2B protein
• Specificity: This antibody reacts to Phosphatidic Acid Phosphatase 2B .
• Buffer: Phosphate buffered saline with 0.08% sodium azide; State: Aff - Purified; State: Liquid purified IgG
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Ship on dry ice. Store (in aliquots) at -20°C to -70°C.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: phospholipid phosphatase 3
• Database Link:
  O14495
• Background: Vascular endothelial growth factor and type I collagen inducible protein (VCIP), also known as phosphatidic acid phosphatase 2b (PAP2b), was originally identified in a functional assay of angiogenesis. VCIP/PAP2b exhibits an Arg - Gly - Asp (RGD) cell adhesion sequence. Immunoprecipitation and fluorescence-activated cell sorting analyses demonstrated that VCIP-RGD is exposed to the outside of the cell surface. Retroviral transduction of VCIP can induce cell aggregation and cell-cell interactions, modestly increase p120 catenin expression and promote activation of the Fak, Akt and GSK3ß protein kinases. Expression of VCIP promoted adhesion, spreading and tyrosine phosphorylation of Fak, Shc, Cas and paxillin in endothelial cells. PAP2b/VCIP is expressed in close proximity to vascular endothelial growth factor, von Willebrand factor and {alpha}vbeta3 integrin in tumor vasculatures.
• Synonyms: PAP2-beta, PAP2B, VCIP

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Ether lipid metabolism, Fc gamma R-mediated phagocytosis, Glycerolipid metabolism, Glycerophospholipid metabolism, Metabolic pathways, Sphingolipid metabolism