CACNG3 Rabbit Polyclonal Antibody
CACNG3 rabbit polyclonal antibody, Purified
|Recommended Dilution||Western Blot: 5 - 10 µg/ml.|
|Reactivities||Human, Mouse, Rat|
|Immunogen||Synthetic peptide derived from the rat calcium channel gamma3 subunit conjugated to KLH|
|Specificity||This antibody reacts to CACNG3.|
|Formulation||Phosphate buffered saline with 0.08% sodium azide
State: Liquid purified Ig
|Storage||The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only.
Avoid repeated freezing and thawing.
|Stability||Shelf life: one year from despatch.|
|Background||Voltage-dependent calcium channels (VDCCs) are large (>400 kDa) heteromers which contain, minimally, three core subunits alpha1, alpha2/delta, beta in a 1:1:1 stoichiometry. Expression of VDCC gene products in Xenopus oocytes, or transfected cells shows that the alpha1 subunits contain the ion channel pore while the auxiliary alpha2/delta and beta subunits confer optimal cell surface expression and channel kinetics1. Until recently, the only exception to the above paradigm was the skeletal muscle VDCC, which, in addition to the alpha1, alpha2/delta, beta core motif, also has an additional tightly associated integral membrane glycoprotein subunit termed gamma 1. Upon co-expression with the alpha1.1, alpha2/delta1, beta1a subunits of the skeletal muscle VDCC, gamma subunits alter the peak currents, and the kinetics of channel activation and inactivation with the overall effect being a normalisation of currents to those resembling the endogenous channel. Together, these results suggest that gamma subunits modulate skeletal muscle VDCCs by stabilising their conformation. The gamma 3 subunit is specifically localized in the brain, with the gamma 2 and gamma 4 subunits. It shares >60% sequence homology with the gamma 2 and gamma 4 subunits and ~25% sequence homology with the gamma 1 and gamma 5 subunits.|
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