Dab1 (N-term) Sheep Polyclonal Antibody

SKU AP05070PU-N

Dab1 (N-term) sheep polyclonal antibody, Purified

Product Data

• Application: WB
• Recommended Dilution: Western Blot: 1-5 μg/ml.; Immunoprecipitation: 5-10 μg/ml.; Positive Control: 293 cells transfected with Dab-1 HA tag.
• Reactivity: Mouse
• Antibody Host: Sheep
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein corresponding to amino acids 1-179 of Mouse disabled coupled to a GST fusion protein.
• Specificity: This antibody recognizes Mouse DAB1 (Disabled 1) (N-term). Other species not tested.
• Buffer: PBS; State: Purified; State: Liquid purified Ig (0.2mm sterile filtered); Preservative: 0.08% Sodium Azide
• Concentration: lot specific
• Purification: Ammonium Sulfate Precipitation
• Conjugation: Unconjugated
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: disabled 1
• Database Link:
  P97318
• Background: Disruption of the disabled-1 gene (Dab1) results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein-protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. Disabled-1 acts downstream of reelin in a signalling pathway.
• Synonyms: Disabled homolog 1

Reference Data