KDELR3 Rabbit Polyclonal Antibody

CAT#: AP01401PU-N

KDELR3 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of KDEL Receptor 3 antibody (Cat.-No.: AP01401PU-N) in extracts from 3T3 cells.

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  Immunohistochemistry (IHC) analyzes of KDEL Receptor 3 antibody (Cat.-No.: AP01401PU-N) in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunohistochemistry on paraffin sections: 1/50-1/200.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: KDEL Receptor 3 antibody detects endogenous levels of KDEL Receptor 3 protein. (region surrounding Leu95)
• Formulation: Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 28 kDa
• Gene Name: KDEL endoplasmic reticulum protein retention receptor 3
• Database Link:
  Entrez Gene 105785 MouseEntrez Gene 11015 Human
  UniProt ID O43731
• Background: Soluble proteins in the endoplasmic reticulum (ER) contain a specific carboxy terminal sequence KDEL (Lys-Asp-Glu-Leu), and include the coat proteins required for vesicle budding from the ER, proteins that form retrogradevesicles on post-ER compartments, and integral membrane proteins that target vesicles to their correct destination. The retention of these soluble proteins in the ER depends on the interaction of the KDEL sequence with the corresponding KDEL receptor, also designated ERD2, in the Golgi apparatus.When KDEL proteins reach the Golgi complex, they are recognized by the KDEL receptor and transported retrograde in COPI-coated vesicles back to the ER. The small GTPase ADP-ribosylation factor 1 (ARF1), a regulator of vesicle transport, interacts with the KDEL receptor.
• Synonyms: ERD2L3

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Vibrio cholerae infection