GRID2 Rabbit Polyclonal Antibody

CAT#: AP01377PU-N

GRID2 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of GluR delta-2 antibody (Cat.-No.: AP01377PU-N) in extracts from 3T3 cells.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: Western Blot: 1/500 - 1/1000.
  Immunofluorescence: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of GluR delta-2 protein. (region surrounding Gly860)
• Formulation: Phosphate buffered saline (PBS), pH~7.2 with 0.05% Sodium Azide as preservative.
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 113 kDa
• Gene Name: glutamate ionotropic receptor delta type subunit 2
• Database Link:
  Entrez Gene 2895 Human
  UniProt ID O43424
• Background: Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamategated, cation-specific ion channels. Kainate/AMPA receptors co-localize with NMDA receptors in many synapses and consist of seven structurally related subunits, designated GluR-1 to -7, as well as GluR-δ2. The kainate/AMPA receptors are primarily responsible for the fast excitatory neurotransmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: ε1, 2, 3, 4 and one ζ subunit. The ζ subunit is expressed throughout the brainstem whereas the four ε subunits display limited distribution. In mice, mutations in the gene encoding GluR-δ2 (GRID2) cause the Lurcher phenotype. The gene encoding human GluR-δ2 maps to chromosome 4q22.
• Synonyms: GluR delta-2, GRID2, GLURD2