CTNND1 Rabbit Polyclonal Antibody

CAT#: AP01354PU-N

CTNND1 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of Catenin-δ1 antibody (Cat.-No.: AP01354PU-N) in extracts from HuvEc cells.

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  Immunohistochemistry (IHC) analyzes of Catenin-δ1 antibody (Cat.-No.: AP01354PU-N) in paraffin-embedded human brain tissue

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunohistochemistry on paraffin sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Catenin-δ1 antibody detects endogenous levels of Catenin-δ1 protein. (region surrounding Gly224)
• Formulation: Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 108 kDa
• Gene Name: catenin delta 1
• Database Link:
  Entrez Gene 1500 Human
  UniProt ID O60716
• Background: The α, β, δ, and γ -catenins are proteins that bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. α-catenin, a 102 kDa protein, interacts with E-cadherin associated protein, and also associates with other members of the cadherin family, such as N-cadherin and P-cadherin. The 92 kDa β-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. β-catenin also complexes with the tumor suppressor protein APC. δ-catenin interacts with Presenilin 1 and is expressed in the brain. The gene encoding δ-catenin maps to human chromosome 5p15.2. A hemizygous loss of the gene encoding δ-catenin leads to the mental retardation associated with Cri-du-Chat syndrome. γ-catenin, also known as plakoglobin, is an 80-88 kDa protein that binds α-catenin and N-cadherin. In addition, the transmembrane phosphatase PTPm associates with catenin/cadherin complexes and may regulate complex signaling.
• Synonyms: CTNND1, KIAA0384, p120 catenin, p120(cas), Delta-Catenin