Melatonin Receptor 1B (MTNR1B) Rabbit Polyclonal Antibody

SKU AP01322PU-N

Melatonin Receptor 1B (MTNR1B) rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: WB
• Recommended Dilution: Western blot: 1/500-1/1000.; Immunohistochemistry: 1/50-1/200.
• Reactivity: Human
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids N-terminus of Human MEL-1B-R.
• Specificity: This antibody detects endogenous levels of MEL-1B-R protein around Val39.
• Buffer: Phosphate buffered saline (PBS), pH~7.2, 50% Glycerol; State: Aff - Purified; State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE); Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Predicted Protein Size: ~40 kDa
• Gene Name: melatonin receptor 1B
• Database Link:
  P49286
• Background: The melatonin receptors, MEL-1A-R and MEL-1B-R, are members of the superfamily of guanine nucleotide-binding regulatory protein (G protein)-coupled receptors. The melatonin receptors are activated by the hormone melatonin (Mel), which is secreted by the pineal gland at night as part of the circadian clock. MEL-1A-R, a 37 kD protein, is thought to be involved in pacing the biological clock. However, both MEL-1A-R and MEL-1B-R are implicated in controlling cellular growth in response to melatonin. MEL-1B-R is an integral membrane protein expressed in retina and less in brain and hippocampus. Functional studies of NIH/3T3 cells stably expressing the MEL-1B-R melatonin receptor indicate that it is coupled to inhibition of adenylyl cyclase.
• Synonyms: MTNR1B

Reference Data