Inositol Hexakisphosphate Kinase 2 (IP6K2) Rabbit Polyclonal Antibody

SKU AP01285PU-N

Inositol Hexakisphosphate Kinase 2 (IP6K2) rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: ELISA, IF, IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.; Immunofluorescence: 1/50-1/200; Immunohistochemistry on Paraffin sections: 1/500-1/200
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 156-204 of Human IP6K2.
• Specificity: This antibody detects endogenous levels of InsP6 kinase 2 / IP6K2 protein (region surrounding Leu188).
• Buffer: Phosphate buffered saline (PBS), pH 7.2; State: Aff - Purified; State: Liquid purified Ig fraction; Preservative: 15 mM Sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Predicted Protein Size: ~ 52 kDa
• Gene Name: inositol hexakisphosphate kinase 2
• Database Link:
  Q9UHH9
• Background: The members of the inositol hexakisphosphate kinase family, IP6K1 and IP6K2, have a high affinity and selectivity for inositol hexakisphosphate (InsP6) as a substrate. IP6K1 and IP6K2 (also designated PiUS) convert InsP6 to PP-InsP5. However, neither kinase demonstrates any catalytic activity with other inositol pyrophosphates. The presence of InsP6, which inhibits serine/threonine protein phosphatases, increases the influx of calcium across the plasma membrane and implies that it may mediate the regulation of insulin exocytosis. IP6K1 was purified as a 54 kDa protein in rat brain extracts. By homology, IP6K1 and IP6K2 were characterized in mouse as a 50 kDa and 49 kDa protein, respectively. IP6K1 displays ATP synthase activity by transferring a phosphate from PP-InsP5 to ADP, which suggests a role for the IP6 kinases as high energy phosphate donors.
• Synonyms: IHPK2, TCCCIA00113, P(i)-uptake stimulator, PiUS

Reference Data