Glucagon Receptor (GCGR) Rabbit Polyclonal Antibody
Product Data | |
Application | IF, WB |
---|---|
Recommended Dilution | Western blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. |
Reactivity | Human, Mouse, Rat |
Antibody Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide corresponding to amino acids 100-150 of Human Glucagon Receptor. |
Specificity | This antibody detects endogenous levels of Glucagon Receptor protein. (region surrounding Lys136) |
Buffer | Phosphate buffered saline (PBS), pH~7.2 State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) Preservative: 15mM Sodium Azide |
Concentration | 1.0 mg/ml |
Purification | Affinity Chromatography using epitope-specific immunogen |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Shipping | Blue Ice |
Predicted Protein Size | ~54 kDa |
Gene Name | glucagon receptor |
Database Link | |
Background | Glucagon, a pancreatic hormone, functions as an antagonist to insulin, stimulating the conversion of glycogen to glucose and increasing blood sugar levels. GLP-1 functions as a transmitter in the central nervous system, inhibiting feeding and drinking behavior. Both glucagon and GLP-1 function through their specific binding to the glucagon receptor or GLP-1R, respectively. The glucagon receptor shows expression in liver, kidney and adipose tissue. The 56 GLP-1R expression primarily localizes to areas of the hypothalamus involved in feeding behavior. Both receptors and their ligands serve as potential targets for the therapeutic treatment of diabetes. |
Synonyms | GCGR, GL-R |
Reference Data | |
Protein Families | Druggable Genome, GPCR, Transmembrane |
Protein Pathways | Neuroactive ligand-receptor interaction |
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