PDE11A Rabbit Polyclonal Antibody

CAT#: AP00662SU-N

PDE11A rabbit polyclonal antibody, Serum

Product Images

Figure 1: Western blot using anti-PDE11A antibody (1:5,000) against lysate from Insect cells transfected with the indicated human PDE isoform.

Specifications

Product Data

• Applications: IHC, IP, WB
• Recommended Dilution: Immunohistochemistry.
  Immunoprecipitation.
  Western blot (1:5000).
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Designed from the C-terminal region common to all known 11A isoforms.
• Specificity: The antibody selectively detects proteins corresponding to members of the PDE11A sub-family (Figure 1).
• Formulation: State: Serum
  State: Liquid diluted serum
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: phosphodiesterase 11A
• Database Link:
  Entrez Gene 50940 Human
  UniProt ID Q9HCR9
• Background: Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3’, 5’-monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling.
  The PDE11 enzyme belongs to a family of PDEs able to hydrolyse both intracellular second messengers, cAMP and cGMP.
• Synonyms: Phosphodiesterase 11A, PDE11A1, PDE11A2, PDE11A3, PDE11A4