PDE7A Rabbit Polyclonal Antibody

CAT#: AP00659SU-N

PDE7A rabbit polyclonal antibody, Serum

Product Images

Western blot using AP00659SU-N (1:2,000) against lysate from COS cells transfected with the indicated human PDE isoform.

Specifications

Product Data

• Applications: IHC, IP, WB
• Recommended Dilution: Western blot.
  Immunohistochemistry.
  Immunoprecipitation.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Designed from the C-terminal region common to the 7A isoform.
• Specificity: The antibody selectively detects proteins corresponding to the PDE7A1 isoform.
• Formulation: State: Serum
  State: Liquid diluted serum
• Conjugation: Unconjugated
• Storage: Store at 4 °C. For long term storage, aliquot and store at -80 °C.
• Stability: Shelf life: One year from despatch.
• Gene Name: phosphodiesterase 7A
• Database Link:
  Entrez Gene 5150 Human
  UniProt ID Q13946
• Background: Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3', 5'-
  monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling.
  The PDE7 enzyme belongs to a family of cAMP-dependent PDEs that provide the major means of inactivating the key intracellular second messenger, cAMP.
  Two genes (PDE7A and PDE7B) encode the PDE7 family, each with multiple splice variants.
• Synonyms: Phosphodiesterase 7A, PDE7, HCP1, TM22