MALT1 Mouse Monoclonal Antibody [Clone ID: SPM578]

SKU AM50100PU-S

MALT1 mouse monoclonal antibody, clone SPM578, Purified

Product Data

• Clone Name: SPM578
• Application: FC, IF, IHC, IP, WB
• Recommended Dilution: ELISA: Use Antibody without BSA for Coating.; Flow Cytometry: 0.5-1 μg/10⁶ cells.; Immunofluorescence: 1-2 μg/ml.; Western Blot: 0.5-1 μg/ml.; Immunoprecipitation: 1-2 μg/500 μg protein lysate.; Immunohistochemistry on Frozen and Formalin-Fixed Paraffin Sections: 0.5-1 μg/ml for 30 minutes at RT.; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.; Positive Control: Jurkat, Daudi or HeLa cells, or lymphoma.
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Human fragment of MALT1 protein (701-808).
• Specificity: Recognizes Human MALT1/Paracaspase. Other species not tested.; Cellular Localization: Cytoplasmic.
• Buffer: 10mM PBS; State: Purified; State: Liquid purified IgG fraction from Bioreactor Concentrate; Stabilizer: 0.05% BSA; Preservative: 0.05% Sodium Azide
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Predicted Protein Size: 93 kDa
• Gene Name: MALT1 paracaspase
• Database Link:
  Q9UDY8
• Background: MALT1/Paracaspase (MALT1) was independently identified as a member of the human paracaspase family and an interacting partner of B-cell lymphoma (Uren et al., 2000). MALT1 is a caspase-like protein that contains an N-terminal death domain, two Ig-like domains, and a C-terminal caspase-like domain. It binds to Bcl-10 through its Ig-like domains and cooperates with Bcl-10 to activate NF-kappaB. MALT1 is thought to play an important role in NF-kappaB signaling by enchancing NF-kappaB activation through interaction with Bcl-10 (Ho et al., 2005). Interaction between MALT1 and Bcl-10 mediates IKK activation in vitro through facilitatiing the ubiquitination of NEMO by the ubiquitinconjugating enzyme UBC13.
• Synonyms: Mucosa-associated lymphoid tissue lymphoma translocation protein 1, MLT, Paracaspase

Reference Data