MICOS10-NBL1 Mouse Monoclonal Antibody [Clone ID: AT38G8]

SKU AM50052PU-N

MICOS10-NBL1 mouse monoclonal antibody, clone AT38G8, Purified

Product Data

• Clone Name: AT38G8
• Application: ELISA, FC, IF, WB
• Recommended Dilution: ELISA.; Flow Cytometry. ; Immunocytochemistry/Immunofluorescence.; Western blot / Immunoblot.; The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant human NBL1 (18-181aa) purified from E. coli
• Buffer: PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol; State: Purified; State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein-A affinity chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: MICOS10-NBL1 readthrough
• Database Link:
  P41271
• Background: NBL1 is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development and alternatively spliced transcript variants have been identified for this gene. Also, as a tumor suppressor gene of neuroblastoma may play an important role in preventing cells from entering the final stage (G1/S) of the transformation process. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 have been observed.
• Synonyms: DAN, DAND1

Reference Data

• Protein Families: Secreted Protein