ARMETL1 (CDNF) Mouse Monoclonal Antibody [Clone ID: 7G5]
| Product Data | |
| Clone Name | 7G5 |
|---|---|
| Application | ELISA, IF, IHC, WB |
| Recommended Dilution | ELISA: 1/5000-1/10000. Western Blot: 1/1000-1/4000. Immunofluorescence: 1/100-1/300. Immunohistochemistry on Paraffin Sections: 1/100-1/200. Formalin-fixed, paraffin-embedded tissues requires antigen retrieval. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Recombinant Human CDNF produced using CHO-based. Antigen is purified from cell culture supernatant. |
| Specificity | Recognizes Human CDNF and not Mouse CDNF. Other species not tested. |
| Buffer | PBS pH 7.4 State: Aff - Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide |
| Concentration | lot specific |
| Purification | Affinity Chromatography on Protein G |
| Conjugation | Unconjugated |
| Storage | Upon receipt, store (in aliquots) at -20°C to -80°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | cerebral dopamine neurotrophic factor |
| Database Link | |
| Background | CDNF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- (Lindholm et al. 20007; Voutilainen et al., 2011) and MPTP-induced degeneration (Airavaara et al., 2012) of dopamine neurons in rodent models of Parkinson’s disease. When administered after 6-OHDA or MPTP –lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta. |
| Synonyms | ARMET-like protein 1, ARMETL1 |
| Reference Data | |
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