RANKL(TNFSF11) Rabbit Polyclonal Antibody

CAT#: AM33178PU-S

Rabbit polyclonal anti-CD254 / RANKL (287-304) antibody, Purified


 Product Datasheet for 'AM33178PU-S'

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USD 205.00


Availability*
2 Weeks

Size
    • 10 ug

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Specifications

Product Data
Recommend Dilution ElISA
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Human sRANKL synthetic Peptide (EEISIEVSNPSLLDPDQD)
Isotype IgG
Formulation 50 mM TRIS pH 7.4
Purification Protein G Chromatography
Predicted Protein Size ~35.3kDa
Gene Name tumor necrosis factor superfamily member 11
Background RANKL is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. There are three isoforms of RANKL. Human RANKL is a soluble 20 kDa polypeptide, comprising the TNF homologous region of RANKL (176 amino acid residues). This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor associated factor (TRAF) 6, which indicated that this protein may have a role in the regulation of cell apoptosis. RANKL deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis.
Synonyms CD254|ODF|OPGL|OPTB2|RANKL|TNLG6B|TRANCE|hRANKL2|sOdf
Reference Data
Protein Families Transmembrane, Druggable Genome
Protein Pathways Cytokine-cytokine receptor interaction
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.