RANKL (TNFSF11) (287-304) Rabbit Polyclonal Antibody

CAT#: AM33178PU-S

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RANKL (TNFSF11) (287-304) rabbit polyclonal antibody, Purified


Product Datasheet for 'AM33178PU-S'


USD 200.00


Availability*
2 Weeks

Size
    • 10 ug


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Specifications

Product Data
Applications ELISA
Recommend Dilution ELISA.
Reactivity Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Human sRANKL synthetic Peptide (EEISIEVSNPSLLDPDQD)
Specificity Recognizes Human sRANKL (soluble form). Other species not tested.
Formulation 50 mM TRIS pH 7.4
State: Purified
State: Lyophilized purified IgG fraction from Serum
Reconstitution Method Restore in aqua bidest to 1 mg/ml
Purification Protein G Chromatography
Gene Name Homo sapiens tumor necrosis factor superfamily member 11 (TNFSF11), transcript variant 1
Background RANKL is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. There are three isoforms of RANKL. Human RANKL is a soluble 20 kDa polypeptide, comprising the TNF homologous region of RANKL (176 amino acid residues). This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor associated factor (TRAF) 6, which indicated that this protein may have a role in the regulation of cell apoptosis. RANKL deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis.
Synonyms OPGL, RANK Ligand, RANKL, TRANCE, TNFSF11, ODF
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction
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