RANKL(TNFSF11) Rabbit Polyclonal Antibody
Rabbit polyclonal anti-CD254 / RANKL (287-304) antibody, Purified
Product Datasheet for 'AM33178PU-N'
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|Immunogen||Human sRANKL synthetic Peptide (EEISIEVSNPSLLDPDQD)|
|Formulation||50 mM TRIS pH 7.4|
|Purification||Protein G Chromatography|
|Predicted Protein Size||~35.3kDa|
|Gene Name||tumor necrosis factor superfamily member 11|
|Background||RANKL is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. There are three isoforms of RANKL. Human RANKL is a soluble 20 kDa polypeptide, comprising the TNF homologous region of RANKL (176 amino acid residues). This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor associated factor (TRAF) 6, which indicated that this protein may have a role in the regulation of cell apoptosis. RANKL deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis.|
|Protein Families||Transmembrane, Druggable Genome|
|Protein Pathways||Cytokine-cytokine receptor interaction|