TIAM1 Mouse Monoclonal Antibody [Clone ID: F5S F6.2]

CAT#: AM33016PU-N

TIAM1 mouse monoclonal antibody, clone F5S F6.2, Purified

Specifications

Product Data

• Clone Name: F5S F6.2
• Applications: IHC, WB
• Recommended Dilution: Western Blot.
  Immunohistochemistry on Frozen Sections.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: T-cell lymphoma invasion and metastasis-inducing protein 1 (Tiam1).
• Specificity: This antibody clone F5S F6.2 is directed against the N-terminal region of Tiam1.
• Formulation: PBS
  State: Purified
  State: Liquid purified IgG fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: T-cell lymphoma invasion and metastasis 1
• Database Link:
  Entrez Gene 7074 Human
  UniProt ID Q13009
• Background: Tiam1, also known as T-cell lymphoma invasion and metastasis-inducing protein 1, is a protein that in humans is encoded by the TIAM1 gene. TIAM1 is tightly associate with BAIAP2 as a subunit. It contains one DH (DBL-homology) domain, one PDZ domain, two PH domains and one Ras-binding RBD domain. TIAM1 modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. In addition, TIAM1 activates Rac1, CDC42, and to a lesser extent RhoA. TIAM1 is found in virtually all tumor cell lines examined including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.
• Synonyms: TIAM-1