GPR48 (LGR4) Rat Monoclonal Antibody [Clone ID: BBX-3A8]

SKU AM32985PU-N

GPR48 (LGR4) rat monoclonal antibody, clone BBX-3A8, Purified

Product Data

• Clone Name: BBX-3A8
• Application: ELISA, FC, WB
• Recommended Dilution: Flow cytometry: 1.2 µg/10⁶ cells.; Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
• Reactivity: Human, Mouse
• Antibody Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: cDNA encoding Human LGR4.
• Specificity: Recognizes LGR4 / GPR48.; Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells.
• Buffer: PBS, pH 7.2; State: Purified; State: Liquid purified IgG fraction
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein G
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: leucine-rich repeat containing G protein-coupled receptor 4
• Database Link:
  Q9BXB1
• Background: LGR4 (Leucine-rich repeat- containing G protein-coupled receptor 4) belongs to the superfamily of G protein-coupled receptors (GPCRs). It is a 951 amino acid multi-pass membrane protein and has multiple N-terminal leucine-rich repeats, which are important for interaction with the glycoprotein ligands, and 7 transmembrane domains (1,3). LGR4 is highly expressed in the adult human pancreas but also with moderate levels of expression in placenta, kidney, brain and heart (2). LGR4 functions as an orphan receptor that may be involved in physiologic activities throughout the cell. It is overexpressed in various cancer types and is thought to enhance carcinoma invasiveness and metastasis, suggesting an important role in tumor progression.
• Synonyms: G-protein coupled receptor 48

Reference Data