Thrombomodulin (THBD) Mouse Monoclonal Antibody [Clone ID: B-S24]
| Product Data | |
| Clone Name | B-S24 |
|---|---|
| Application | ELISA |
| Recommended Dilution | ELISA. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Eahy 926 cell lines. |
| Specificity | Recognises Thrombomodulin (TM), a 105 kDa protein. |
| Buffer | 0.22 µm Sterile-filtered PBS. Carrier and preservative free. State: Azide Free State: Liquid purified IgG fraction |
| Concentration | lot specific |
| Purification | Ion Exchange Chromatography |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for up to 12 months. For longer storage freeze aliquots. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | thrombomodulin |
| Database Link | |
| Background | CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure. |
| Synonyms | Thrombomodulin, THRM, Fetomodulin |
| Reference Data | |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Complement and coagulation cascades |
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