Thrombomodulin (THBD) Mouse Monoclonal Antibody [Clone ID: B-S24]

CAT#: AM31361AF-N

Thrombomodulin (THBD) mouse monoclonal antibody, clone B-S24, Azide Free

Specifications

Product Data

• Clone Name: B-S24
• Applications: ELISA
• Recommended Dilution: ELISA.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Eahy 926 cell lines.
• Specificity: Recognises Thrombomodulin (TM), a 105 kDa protein.
• Formulation: 0.22 µm Sterile-filtered PBS.
  Carrier and preservative free.
  State: Azide Free
  State: Liquid purified IgG fraction
• Concentration: lot specific
• Purification: Ion Exchange Chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for up to 12 months.
  For longer storage freeze aliquots.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens thrombomodulin (THBD)
• Database Link:
  Entrez Gene 7056 Human
  UniProt ID P07204
• Background: CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.
• Synonyms: Thrombomodulin, THRM, Fetomodulin

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Complement and coagulation cascades