LARGE (LARGE1) (35-142) Mouse Monoclonal Antibody [Clone ID: LARGE-02]

SKU AM26764PU-N

LARGE (LARGE1) (35-142) mouse monoclonal antibody, clone LARGE-02, Purified

Product Data

• Clone Name: LARGE-02
• Application: FC, WB
• Recommended Dilution: Flow cytometry.; Western blot.
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Recombinant fragment of human LARGE1 (amino acids 35-142)
• Specificity: This antibody recognizes human LARGE1, a glycosyltransferase localizing mainly to the Golgi apparatus. Crossreactivity with LARGE2 was not determined.
• Buffer: Phosphate buffered saline (PBS); State: Purified; State: Liquid Ig fraction; Preservative: 15 mM sodium azide, approx. pH 7.4
• Concentration: lot specific
• Purification: Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C.; DO NOT FREEZE!
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: LARGE xylosyl- and glucuronyltransferase 1
• Database Link:
  O95461
• Background: LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.
• Synonyms: LARGE, KIAA0609, LARGE1, Glycosyltransferase-like protein LARGE1, Acetylglucosaminyltransferase-like 1A

Reference Data