Claudin 6 (CLDN6) Rat Monoclonal Antibody [Clone ID: YD-9H8]
| Product Data | |
| Clone Name | YD-9H8 |
|---|---|
| Application | ELISA, FC, WB |
| Recommended Dilution | Flow cytometry: 1.2 µg/106 cells. ELISA: 1/200-1/400. CELISA: 1/200-1/400. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400. |
| Reactivity | Human |
| Antibody Host | Rat |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Immunogen | cDNA encoding Human Claudin 9. Selection: based on recognition of the complete native protein expressed on transfected mammalian cells. |
| Specificity | This antibody detects Human Claudin-6 and Claudin-9. |
| Buffer | PBS, pH 7.2 State: Purified State: Liquid purified Ig fraction Preservative: None |
| Concentration | lot specific |
| Purification | Protein G Chromatography |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | claudin 6 |
| Database Link | |
| Background | Claudin 6 and Claudin 9 belong to the claudin family which constitutes a large group of four - transmembrane domain proteins (1) . Claudins are integral tight junction proteins that are responsible for maintaining the integrity of epithelial cell architecture, the control of parace llular transport and cell polarity. The expression pattern of claudins is tissue specific, most tissues express multiple claudins, which can interact in both homotypic and heterotypic fashion to form the tight junction strands (2) . Several claudin proteins have been shown to be abnormally expressed in cancers. The differential expression of these proteins between tumour and normal cells, in addition to their membrane localisation, makes them prime candidates for cancer therapy (2). Members of the claudin fa mily, including Claudin 6 and 9 are expressed in the liver and play a critical role in Hepatitis C Infection. They function as coreceptors in HCV entry and assume a role in HCV dissemination, replication and pathogenesis (3). |
| Synonyms | CLDN6, PRO1488, Skullin, Skullin 2, UNQ757, CLDN9 |
| Reference Data | |
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