Claudin 9 (CLDN9) Rat Monoclonal Antibody [Clone ID: YD-4E9]

CAT#: AM26751PU-N

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Claudin 9 (CLDN9) rat monoclonal antibody, clone YD-4E9, Purified



USD 429.00


Availability*
2 Weeks

Size
    • 100 ug


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Specifications

Product Data
Clone Name YD-4E9
Applications ELISA, FC
Recommended Dilution Flow Cytometry: 1.2 µg / 106 cells.
ELISA: 1/200-1/400.
Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
CELISA: 1/200-1/400.
Reactivity Human
Host Rat
Isotype IgG2b
Clonality Monoclonal
Immunogen cDNA encoding Human Claudin 9. 
Selection: based on recognition of the complete native protein expressed on transfected mammalian cells.
Specificity This antibody detects Human Claudin-9. Other species not tested.
Formulation PBS, pH 7.2
State: Purified
State: Liquid purified Ig fraction
Preservative: None
Concentration lot specific
Purification Protein G Chromatography
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background Claudin 9 belongs to the claudin family which constitutes a large group of four - transmembrane domain proteins (1). Claudins are integral tight junction proteins that are responsible for maintaining the integrity of epithelial cell architecture, the control of paracellular transport and c ell polarity. The expression pattern of claudins is tissue specific, most tissues express multiple claudins, which can interact in both homotypic and heterotypic fashion to form the tight junction strands (2). Several claudin proteins have been shown to be abnormally expressed in cancers. The differential expression of these proteins between tumour and normal cells, in addition to their membrane localisation, makes them prime candidates for cancer therapy (2). Members of the claudin family, including Claudi n 6 and 9 are expressed in the liver and play a critical role in Hepatitis C Infection. They function as coreceptors in HCV entry and assume a role in HCV dissemination, replication and pathogenesis (3,4) .
Synonyms CLDN9
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.