Claudin 9 (CLDN9) Rat Monoclonal Antibody [Clone ID: YD-4E9]
| Product Data | |
| Clone Name | YD-4E9 |
|---|---|
| Application | ELISA, FC |
| Recommended Dilution | Flow Cytometry: 1.2 µg / 106 cells. ELISA: 1/200-1/400. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400. CELISA: 1/200-1/400. |
| Reactivity | Human |
| Antibody Host | Rat |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Immunogen | cDNA encoding Human Claudin 9. Selection: based on recognition of the complete native protein expressed on transfected mammalian cells. |
| Specificity | This antibody detects Human Claudin-9. Other species not tested. |
| Buffer | PBS, pH 7.2 State: Purified State: Liquid purified Ig fraction Preservative: None |
| Concentration | lot specific |
| Purification | Protein G Chromatography |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | claudin 9 |
| Database Link | |
| Background | Claudin 9 belongs to the claudin family which constitutes a large group of four - transmembrane domain proteins (1). Claudins are integral tight junction proteins that are responsible for maintaining the integrity of epithelial cell architecture, the control of paracellular transport and c ell polarity. The expression pattern of claudins is tissue specific, most tissues express multiple claudins, which can interact in both homotypic and heterotypic fashion to form the tight junction strands (2). Several claudin proteins have been shown to be abnormally expressed in cancers. The differential expression of these proteins between tumour and normal cells, in addition to their membrane localisation, makes them prime candidates for cancer therapy (2). Members of the claudin family, including Claudi n 6 and 9 are expressed in the liver and play a critical role in Hepatitis C Infection. They function as coreceptors in HCV entry and assume a role in HCV dissemination, replication and pathogenesis (3,4) . |
| Synonyms | CLDN9 |
| Reference Data | |
Write Your Own Review
| Product Manuals |
| FAQs |
| SDS |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.