Integrin alpha E (ITGAE) Mouse Monoclonal Antibody [Clone ID: Ber-ACT8]

SKU AM26142PU-N

Integrin alpha E (ITGAE) mouse monoclonal antibody, clone Ber-ACT8, Aff - Purified

Product Data

• Clone Name: Ber-ACT8
• Application: FC, IHC, IP, WB
• Recommended Dilution: Flow cytometry.; Immunoprecipitation.; Western blot.; Immunohistochemistry (frozen sections).
• Reactivity: Human, Primate
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: HTLV-1 induced human T cell line MAPS16
• Specificity: This antibody recognizes CD103 (alpha E integrin), a type I transmembrane glycoprotein primarily found on intestinal intraepithelial lymphocytes.
• Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4; State: Aff - Purified; State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 to -70 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: integrin subunit alpha E
• Database Link:
  P38570
• Background: CD103 / Integrin alphaE is an integrin subunit that is expressed on intraepithelial lymphocytes, epithelial dendritic cells, lamina propria-derived dendritic cells, a subpopulation of lamina propria T cells, a small subset of peripheral lymphocytes, namely T reg cells, and on activated and TGF-beta stimulated lymphocytes. CD103 is in mature form cleaved into two disulfide-linked chains (C-terminal 150 kDa chain and N-terminal 25 kDa chain). It heterodimerizes with integrin beta7 subunit to form alphaE/beta7 integrin (mucosal lymphocyte 1 antigen), which through binding E-cadherin mediates homing of lymphocytes to the intestinal epithelium, and, in addition to the role in adhesion, may serve as an accessory molecule for intraepithelial lymphocyte activation.
• Synonyms: Integrin alpha-E, Integrin alpha-IEL, HML-1 antigen, ITGAE

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Regulation of actin cytoskeleton