UBN1 (1-190) Mouse Monoclonal Antibody [Clone ID: UBN1-02]
UBN1 (1-190) mouse monoclonal antibody, clone UBN1-02, Aff - Purified
Western blot: 1-5 μg/ml; Positive control: HeLa cell line.
|Immunogen||Recombinant protein corresponding to amino acids 1-190 of ubinuclein 1|
|Specificity||This antibody recognizes N-terminal part of ubinuclein 1 (UBN1), a widely expressed nuclear and adhesion complex protein. Western blotting analysis reveals UBN1 as a 165 kDa band.|
|Formulation||Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
State: Aff - Purified
State: Liquid Ig fraction
|Purification||Protein-A affinity chromatography (> 95% pure by SDS-PAGE)|
|Storage||Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.|
|Stability||Shelf life: one year from despatch.|
|Gene Name||Homo sapiens ubinuclein 1 (UBN1), transcript variant 1|
|Background||Ubinuclein 1 (UBN1) is a ubiquitously expressed evolutionarily conserved protein which binds to proliferation-promoting genes that are repressed by formation of senescence-associated heterochromatin foci (SAHF). Ubinuclein 1 associates with various transcription factors and with histone methyltransferase activity, is indispensable for SAHF formation and appears to be a regulator of senescence. Although in most cells ubinuclein is localized to the nucleus, in cells forming tight junctions it is recruited to the cell adhesion complexes, dependently on the cell density.|
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