CCDC98 (FAM175A) (N-term) Mouse Monoclonal Antibody [Clone ID: ABRA1-01]

SKU AM12137PU-N

CCDC98 (FAM175A) (N-term) mouse monoclonal antibody, clone ABRA1-01, Aff - Purified

Product Data

• Clone Name: ABRA1-01
• Application: FC, IHC, IP, WB
• Recommended Dilution: Flow Cytometry: 1-2 µg/ml.; Immunoprecipitation.; Western blot (Reducing Conditions).; This clone has been described to work in Immunohistochemistry on Paraffin Sections.
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag
• Specificity: This monoclonal antibody ABRA1-01 recognizes N-terminal part of ABRA1 (Abraxas, CCDC98), an adaptor protein involved in DNA repair, which migrates as a 45 kDa band on PAAGE under reducing conditions.
• Buffer: PBS, pH~7.4; State: Aff - Purified; State: Liquid purified Ig fraction (> 95% by SDS-PAGE); Preservative: 15mM Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: family with sequence similarity 175 member A
• Database Link:
  Q6UWZ7
• Background: ABRA1 (Abraxas), also known as CCDC98, is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.
• Synonyms: Protein FAM175A, ABRA1, Abraxas

Reference Data