PDGF Receptor beta (PDGFRB) Mouse Monoclonal Antibody [Clone ID: 18A2]

CAT#: AM12129PU-N

PDGF Receptor beta (PDGFRB) mouse monoclonal antibody, clone 18A2, Purified

Product Images

Surface staining of CD140b / PDGF-RB in human CD140b / PDGF-RB stable transfectants with anti-CD140b (18A2) purified GAM-APC.

Specifications

Product Data

• Clone Name: 18A2
• Applications: FC, IF, IHC
• Recommended Dilution: Flow Cytometry: 1-5 µg/ml.
  Immmunocytochemistry.
  Immunohistochemistry on Frozen Sections.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: CD140b-transfected NIH 3T3 cells
• Specificity: This antibody recognizes CD140b / PDGF-RB, the 180-190 kDa beta chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative roles.
• Formulation: PBS, pH~7.4
  State: Purified
  State: Liquid purified Ig fraction from Cell Culture Supernatant (> 95% pure by SDS-PAGE)
  Preservative: 15 mM Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C.
  DO NOT FREEZE!
  
• Stability: Shelf life: one year from despatch.
• Gene Name: platelet derived growth factor receptor beta
• Database Link:
  Entrez Gene 5159 Human
  UniProt ID P09619
• Background: CD140b / PDGF-RB (platelet-derived growth factor receptor beta) is a cell surface receptor for members of platelet-derived growth factor family, whose intracellular part contains a tyrosine kinase domain. CD140b forms homodimers, or heterodimerizes with CD140a / PDGF-RA. Whereas CD140a can have both pro-proliferative or anti-proliferative effects, the CD140b induces in various cell types their proliferation and migration. CD140b has also developmental roles in the cardiovascular system and is preferentially expressed on some tumours such as medulloblastoma.
• Synonyms: PDGF-R-beta, PDGF Receptor beta

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
• Protein Pathways: Calcium signaling pathway, Colorectal cancer, Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton