CD62L (SELL) Mouse Monoclonal Antibody [Clone ID: DREG56]

SKU AM12066LE-N

CD62L (SELL) mouse monoclonal antibody, clone DREG56, Low Endotoxin

Product Data

• Clone Name: DREG56
• Application: FC, FN, IHC, IP, WB
• Recommended Dilution: Flow cytometry: 2 μg/ml.; Immunoprecipitation.; Western blot: non-reducing conditions.; Immunohistochemistry (frozen sections).; Functional application: Particularly effective in blocking of lymphocyte CD62L-mediated binding to peripheral lymph node HEV.
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: PMA-activated human peripheral blood leukocytes
• Specificity: This antibody recognizes CD62L / L-selectin, a 65-76 kDa cell surface protein, expressed by neutrophils, monocytes, and subsets of T, B, and NK cells, that interacts with specific carbohydrates exposed on activated endothelial cells.
• Buffer: Buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized; State: Low Endotoxin; State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C.; DO NOT FREEZE!
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: selectin L
• Database Link:
  P14151
• Background: CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cell surface of leukocytes and mediates their homing to inflammatory sites and peripheral lymph nodes by enabling rolling along the venular wall. CD62L is also involved in activation-induced neutrophil aggregation. Activation-dependent CD62L shedding, however, counteracts neutrophil rolling. CD62L has also signaling roles including enhance of chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1 (P-selectin glycoprotein ligand-1). The level of CD62L expression can be used to help distinguish naive T cells from effector/memory T cells.
• Synonyms: SELL, LNHR, LYAM1, Leu-8, TQ1, gp90-MEL, LECAM1, LAM-1

Reference Data