ADK (22-362) Mouse Monoclonal Antibody [Clone ID: AT4F8]

SKU AM09394PU-S

ADK (22-362) mouse monoclonal antibody, clone AT4F8, Purified

Product Data

• Clone Name: AT4F8
• Application: ELISA, FC, IF, WB
• Recommended Dilution: ELISA.; Western blot (1:1000).; Immunocytochemistry / Immunoflourescence.; Flow cytometry.
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant human ADK (22-362aa) purified from E. coli
• Specificity: The antibody recognizes human Adenosine kinase at aa 22-362. Other species not tested.
• Buffer: PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol; State: Purified; State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein-G affinity chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: adenosine kinase
• Database Link:
  P55263
• Background: Adenosine kinase (ADK) is the key regulator of adenosine metabolism. Because of the manifold receptor-dependent actions of adenosine, tight regulation of adenosine levels is crucial. The intracellular and extracellular pools of adenosine are in dynamic exchange by equilibrative and concentrative nucleoside transporters, so extracellular concentrations of adenosine are regulated by interplay of theses transporters with intracellular and extracellular enzymes of adenosine metabolism. Thus, the extracellular concentration of adenosine is enhanced by inhibition of equilibrative nucleoside transporters such as S-(4-nitrobenzyl)-6-thioinosine and cannabidiol and, stimulation of extracellular ATP breakdown and inhibition of intracellular adenosine removal.
• Synonyms: ADK, AK

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Purine metabolism