TDP1 Mouse Monoclonal Antibody [Clone ID: AT1F2]

SKU AM09086PU-N

TDP1 mouse monoclonal antibody, clone AT1F2, Purified

Product Data

• Clone Name: AT1F2
• Application: ELISA, IHC, WB
• Recommended Dilution: ELISA.; Western blot: 1/1,000-1/2,000.; Immunohistochemistry on Paraffin Sections: 5 µg/ml.
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Recombinant Human TDP1 (1-298 aa) purified from E. coli
• Specificity: The antibody recognizes Human TDP1. Other species not tested.
• Buffer: PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol; State: Purified; State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein G
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: tyrosyl-DNA phosphodiesterase 1
• Database Link:
  Q9NUW8
• Background: Tyrosyl-DNA phosphodiesterase (TDP1) is a DNA repair enzyme that catalyzes the hydrolysis of a phophodiester bond between a tyrosine residue and a DNA 3' phosphate. This protein is a member of the phospholipase D (PLD) superfamily and contains two PLD phosphodiesterase domains. Mutations in TDP1 are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1) by interfering with DNA transcription or by inducting apoptosis in postmitotic neurons.
• Synonyms: Tyrosyl-DNA phosphodiesterase 1

Reference Data

• Protein Families: Druggable Genome