alpha Synuclein (SNCA) (also beta reactive) Mouse Monoclonal Antibody [Clone ID: 3B6]

CAT#: AM09033PU-S

alpha Synuclein (SNCA) (also beta reactive) mouse monoclonal antibody, clone 3B6, Purified

Product Images

The recombinant human synuclein family (alpha-, beta- and gamma-) (each 20ng), Mouse brain and Rat brain (30ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human alpha, beta-synuclein (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

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  Western blot analysis: Lane 1 = a- synuclein, Lane 2 = β- synuclein, Lane 3 = ?- synuclein, Lane 4 = Mouse brain, Lane 3 = Rat brain. The recombinant human synuclein family (a-, β- and ?-) (each 20 ng), Mouse brain and Rat brain (30 ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human a-synuclein (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Specifications

Product Data

• Clone Name: 3B6
• Applications: ELISA, FC, IF, WB
• Recommended Dilution: ELISA.
  Western blot (1/1,000-1/2,000).
  Flow Cytometry.
  Immunofluorescence.
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant human α-synuclein (119-140aa) purified from E. coli
• Specificity: The antibody recognizes α,β - Synuclein.
• Formulation: PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein-G affinity chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: synuclein alpha
• Database Link:
  Entrez Gene 6622 Human
  UniProt ID P37840
• Background: α-synuclein (amino acids 119-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. α-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Specially, the non-Aβ component of amyloid plaques is a highly amyloidogenic peptide consisting of 35 amino acids which was first identified associated with senile plaques in the Alzheimer's disease brain.
• Synonyms: NACP, PARK1