KCNQ1 Mouse Monoclonal Antibody [Clone ID: 5E12]

CAT#: AM06707SU-N

KCNQ1 mouse monoclonal antibody, clone 5E12, Ascites

Product Images

Western blot analysis using KCNQ1 mAb against human KCNQ1 (AA: 229-347) recombinant protein. (Expected MW is 74.7 kDa)

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  Western blot analysis using KCNQ1 mouse mAb against MCF-7 (1) and A431 (2) cell lysate.

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  Red: Control Antigen (100ng) Purple: Antigen (10ng) Green: Antigen (50ng) Blue: Antigen (100ng)

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  Flow cytometric analysis of MCF-7 cells using KCNQ1 mouse mAb (green) and negative control (red).

Specifications

Product Data

• Clone Name: 5E12
• Applications: ELISA, FC, WB
• Recommended Dilution: Western Blot: 1/500 - 1/2000.
  Flow cytometry: 1/200 - 1/400.
  ELISA: 1/10000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of human KCNQ1 expressed in E. Coli.
  
• Specificity: This antibody reacts to KCNQ1.
• Formulation: State: Ascites
  State: Ascitic fluid containing 0.03% sodium azide.
  
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: 95 kDa
• Gene Name: potassium voltage-gated channel subfamily Q member 1
• Database Link:
  Entrez Gene 3784 Human
  UniProt ID P51787
• Background: This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene.
• Synonyms: KCNA8, KCNA9, KVLQT1, KQT-like 1, Potassium voltage-gated channel subfamily KQT member 1, Voltage-gated potassium channel subunit Kv7.1