c Kit (KIT) Mouse Monoclonal Antibody [Clone ID: 1C5]

SKU AM06670SU-N

c Kit (KIT) mouse monoclonal antibody, clone 1C5, Ascites

Product Data

• Clone Name: 1C5
• Application: ELISA, IHC, WB
• Recommended Dilution: Western Blot: 1/500 - 1/2000.; Immunohistochemistry on paraffin sections: 1/200 - 1/1000.; ELISA: 1/10000.
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of human KIT expressed in E. Coli.
• Specificity: This antibody reacts to KIT.
• Buffer: State: Ascites; State: Ascitic fluid containing 0.03% sodium azide.
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Predicted Protein Size: 145 kDa
• Gene Name: KIT proto-oncogene receptor tyrosine kinase
• Database Link:
  P10721
• Background: The c-Kit proto-oncogene is a member of the receptor tyrosine kinase family and, more specifically, is closely related to the platelet derived growth factor receptor (PDGFR). c-Kit, the normal cellular homolog of the HZ4-feline sarcoma virus transforming gene (v-Kit), encodes a transmembrane receptor. c-Kit regulates a variety of biological responses including chemotaxis, cell prolif- eration, apoptosis and adhesion. c-Kit is also identical with the product of the W locus in mice and, as such, is integral to the development of mast cells and hematopoiesis. The ligand for the c-Kit receptor (KL) has been identified and is encoded at the murine steel (SI) locus. Kit is the human homolog of the proto- oncogene c-Kit. Mutations in Kit are integral for tumor growth and progression in various cancers.
• Synonyms: SCFR, KIT

Reference Data