Cortactin (CTTN) Mouse Monoclonal Antibody [Clone ID: 4C6]

SKU AM06601SU-N

Cortactin (CTTN) mouse monoclonal antibody, clone 4C6, Ascites

Product Data

• Clone Name: 4C6
• Application: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/10000.; Western Blot: 1/500 - 1/2000.; Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000.
• Reactivity: Human, Mouse
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of Human CTTN expressed in E. Coli.
• Specificity: Recognizes CTTN
• Buffer: State: Ascites; State: Ascitic fluid containing 0.03% Sodium Azide.
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Predicted Protein Size: 80 kDa
• Gene Name: cortactin
• Database Link:
  Q14247
• Background: This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
• Synonyms: CTTN, EMS1, Amplaxin, Oncogene EMS1

Reference Data