IRE1 (ERN1) (282-433) Mouse Monoclonal Antibody [Clone ID: 9F2]
| Product Data | |
| Clone Name | 9F2 |
|---|---|
| Application | ELISA, IHC, WB |
| Recommended Dilution | ELISA: 1/10000 Western blot: 1/500-1/2000. Immunofluorescence: 1/200-1/1000. Immunohistochemistry on Paraffin Sections: 1/200-1/1000. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Purified recombinant fragment of Human ERN1 (aa282-433) expressed in E. Coli. |
| Specificity | Recognizes ER To Nucleus Signaling 1 (IRE1/ERN1). |
| Buffer | State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide. |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | 109 kDa |
| Gene Name | endoplasmic reticulum to nucleus signaling 1 |
| Database Link | |
| Background | IRE1p is a 108kDa serine-threonine kinase/endoribonuclease also known as ERN1. It is an endoplasmic reticulum (ER) transmembrane protein, normally bound to the ER molecular chaperones GRP78 and GRP94. At times of ER stress, due to accumulation of unfolded proteins, IRE1p becomes dissociated from the chaperones, which allows it to activate the un-folded protein transcriptional response (UPR). In the mammalian genome, there are two homologs Ire1alpha and Ire1beta. Ire1alpha is expressed in all cells and tissues, Ire1beta expression is primarily restricted to intestinal epithelial cells. |
| Synonyms | Inositol-requiring protein 1, IRE1p, Ire1-alpha, IRE1a |
| Reference Data | |
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