LYRIC (MTDH) Mouse Monoclonal Antibody [Clone ID: 2F11C3]

SKU AM06379PU-N

LYRIC (MTDH) mouse monoclonal antibody, clone 2F11C3, Aff - Purified

Product Data

• Clone Name: 2F11C3
• Application: ELISA, FC, IHC, WB
• Recommended Dilution: Western Blot: 1/500 - 1/2000.; Immunohistochemistry on paraffin sections: 1/200 - 1/1000.; Flow cytometry: 1/200 - 1/400.; ELISA: 1/10000.
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of human Metadherin expressed in E. Coli.
• Specificity: This antibody reacts to Metadherin.
• Buffer: PBS; State: Aff - Purified; State: Liquid purified Ig fraction; Stabilizer: 50% glycerol; Preservative: 0,03% sodium azide
• Purification: Affinity chromatography on Protein G
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Predicted Protein Size: 64 kDa
• Gene Name: metadherin
• Database Link:
  Q86UE4
• Background: Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.
• Synonyms: 3D3/LYRIC, Metastasis adhesion protein, AEG1, LYRIC, Metadherin, AEG-1

Reference Data